![]() A 24-hour urine sample will be collected from adults who are able and willing in children and in those not able or unwilling to provide a 24-hour urine, a spot urine will be collected.Laboratory studies will be performed in all patients.A urine pregnancy test will be done in all females of childbearing potential.Photos of the affected area(s) will be taken, however, this is optional.The height, weight, body mass index and Tanner stage measurements will be recorded during this visit.They will be asked specific questions regarding medical and family history and an intake form will be filled out. ![]() Fgfr3 isoforms caused overgrowth of long bones and vertebrae (21, 22). 1 Heterotopic bone often forms around the hip or elbow joints, making bending of these joints difficult. Most people who develop heterotopic ossification cannot feel the abnormal bone, but notice the bone growth getting in the way of normal movements. The study will consist of 15 participants, all who have a known clinical diagnosis of an overgrowth syndrome, and will be >5 years old so that they can co operate with a DEXA or Xtreme CT scan. In addition, Fgfr3c/ mice exhibited decreased bone mineral density in the. The most common symptom of heterotopic ossification is stiffness of a joint. If they are found to be at a particular risk for decreased bone density then this can be addressed in early childhood, through nutrition and activity recommendations. This study will look at bone health in patient's with OGS in a cross sectional fashion. However, what is not known is if patients with OGS are at decreased bone density at locations that are distant from the vascular malformation. It is known that patients with complex vascular malformation are at risk of decreased bone density and even vanishing bone disease. Why Should I Register and Submit Results?. ![]()
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